Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands

Piotr Raubo; Margaret S Beer; Peter A Hunt; Ian T Huscroft; Clare London; Josephine A Stanton; Janusz J Kulagowski

doi:10.1016/j.bmcl.2005.11.067

Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1255-8. doi: 10.1016/j.bmcl.2005.11.067. Epub 2005 Dec 7.

Authors

Piotr Raubo¹, Margaret S Beer, Peter A Hunt, Ian T Huscroft, Clare London, Josephine A Stanton, Janusz J Kulagowski

Affiliation

¹ The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex CM20 2QR, UK. piotr_raubo@merck.com

PMID: 16337790
DOI: 10.1016/j.bmcl.2005.11.067

Abstract

A novel series of 5-HT(7) receptor ligands has been identified and evaluated, providing compounds showing a broad spectrum of functional activities and good selectivity over selected receptors and ion channels.

MeSH terms

Alkylation
Amination
Cyclization
Ligands
Molecular Structure
Receptors, Serotonin / chemistry*
Receptors, Serotonin / metabolism*
Structure-Activity Relationship
Sulfones / chemical synthesis
Sulfones / chemistry*
Sulfones / metabolism*

Substances

Ligands
Receptors, Serotonin
Sulfones